5DG0

Human APE1 phosphorothioate substrate complex with Mn2+

Summary for 5DG0

• Entry DOI: 10.2210/pdb5dg0/pdb
• Descriptor: DNA-(apurinic or apyrimidinic site) lyase, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(OMC)P*(48Z)P*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*AP*TP*CP*CP*GP*TP*CP*GP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... (7 entities in total)
• Functional Keywords: hydrolase and lyase - dna complex, hydrolase, lyase-dna complex, lyase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 75968.73

Authors

Freudenthal, B.D.,Wilson, S.H. (deposition date: 2015-08-27, release date: 2015-10-14, Last modification date: 2023-09-27)

• Primary citation: Freudenthal, B.D.,Beard, W.A.,Cuneo, M.J.,Dyrkheeva, N.S.,Wilson, S.H.; Capturing snapshots of APE1 processing DNA damage.; Nat.Struct.Mol.Biol., 22:924-931, 2015; PubMed: 26458045; DOI: 10.1038/nsmb.3105

Experimental method

X-RAY DIFFRACTION (1.8 Å)