5DDE

Menin in complex with MI-859

Summary for 5DDE

Entry DOI	10.2210/pdb5dde/pdb
Related	5DB0 5DB1 5DB2 5DB3 5DD9 5DDA 5DDB 5DDC 5DDD 5DDF
Descriptor	Menin, 6-(2,2-difluoroethyl)-4-[4-(5,5-dimethyl-4,5-dihydro-1,3-thiazol-2-yl)piperazin-1-yl]thieno[2,3-d]pyrimidine, SULFATE ION, ... (7 entities in total)
Functional Keywords	protein binding-inhibitor complex, protein binding/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	56318.32
Authors	Pollock, J.,Dmitry, B.,Cierpicki, T.,Grembecka, J. (deposition date: 2015-08-24, release date: 2015-09-09, Last modification date: 2023-09-27)
Primary citation	Pollock, J.,Borkin, D.,Lund, G.,Purohit, T.,Dyguda-Kazimierowicz, E.,Grembecka, J.,Cierpicki, T. Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes. J.Med.Chem., 58:7465-7474, 2015 Cited by PubMed: 26288158 DOI: 10.1021/acs.jmedchem.5b00975 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.78 Å)

Structure validation