5DDA

Menin in complex with MI-333

Summary for 5DDA

Entry DOI	10.2210/pdb5dda/pdb
Related	5DB0 5DB1 5DB2 5DB3 5DD9 5DDB 5DDC 5DDD 5DDE 5DDF
Descriptor	Menin, 4-{4-[5-(fluoromethyl)-1,3,4-thiadiazol-2-yl]piperazin-1-yl}-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine, DIMETHYL SULFOXIDE, ... (7 entities in total)
Functional Keywords	protein binding-inhibitor complex, protein binding/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	56143.92
Authors	Pollock, J.,Dmitry, B.,Cierpicki, T.,Grembecka, J. (deposition date: 2015-08-24, release date: 2015-09-09, Last modification date: 2023-09-27)
Primary citation	Pollock, J.,Borkin, D.,Lund, G.,Purohit, T.,Dyguda-Kazimierowicz, E.,Grembecka, J.,Cierpicki, T. Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes. J.Med.Chem., 58:7465-7474, 2015 Cited by PubMed: 26288158 DOI: 10.1021/acs.jmedchem.5b00975 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.83 Å)

Structure validation