5DBM

Crystal structure of the CBP bromodomain in complex with CPI703

Summary for 5DBM

• Entry DOI: 10.2210/pdb5dbm/pdb
• Related: 4YK0
• Descriptor: CREB-binding protein, (4R)-6-(1-tert-butyl-1H-pyrazol-4-yl)-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one (3 entities in total)
• Functional Keywords: bromodomain, inhibitor, epigenetics, chromatin, protein binding
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: Q92793
• Total number of polymer chains: 3
• Total formula weight: 42871.18

Authors

Setser, J.W.,Poy, F.,Bellon, S.F. (deposition date: 2015-08-21, release date: 2016-04-20, Last modification date: 2023-09-27)

• Primary citation: Ghosh, S.,Taylor, A.,Chin, M.,Huang, H.R.,Conery, A.R.,Mertz, J.A.,Salmeron, A.,Dakle, P.J.,Mele, D.,Cote, A.,Jayaram, H.,Setser, J.W.,Poy, F.,Hatzivassiliou, G.,DeAlmeida-Nagata, D.,Sandy, P.,Hatton, C.,Romero, F.A.,Chiang, E.,Reimer, T.,Crawford, T.,Pardo, E.,Watson, V.G.,Tsui, V.,Cochran, A.G.,Zawadzke, L.,Harmange, J.C.,Audia, J.E.,Bryant, B.M.,Cummings, R.T.,Magnuson, S.R.,Grogan, J.L.,Bellon, S.F.,Albrecht, B.K.,Sims, R.J.,Lora, J.M.; Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition.; J.Biol.Chem., 291:13014-13027, 2016; PubMed: 27056325; DOI: 10.1074/jbc.M115.708560

Experimental method

X-RAY DIFFRACTION (1.86 Å)