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5DB1

Menin in complex with MI-336

Summary for 5DB1
Entry DOI10.2210/pdb5db1/pdb
Related5DB0 5DB2 5DB3
DescriptorMenin, 6-methoxy-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indole-2-carbonitrile, DIMETHYL SULFOXIDE, ... (6 entities in total)
Functional Keywordsprotein binding, protein binding-inhibitor complex, protein binding/inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight56368.15
Authors
Pollock, J.,Dmitry, B.,Cierpicki, T.,Grembecka, J. (deposition date: 2015-08-20, release date: 2016-03-30, Last modification date: 2023-09-27)
Primary citationBorkin, D.,Pollock, J.,Kempinska, K.,Purohit, T.,Li, X.,Wen, B.,Zhao, T.,Miao, H.,Shukla, S.,He, M.,Sun, D.,Cierpicki, T.,Grembecka, J.
Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL).
J.Med.Chem., 59:892-913, 2016
Cited by
PubMed: 26744767
DOI: 10.1021/acs.jmedchem.5b01305
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.86 Å)
Structure validation

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