5DA3

Crystal structure of PTK6 Kinase domain with inhibitor

Summary for 5DA3

• Entry DOI: 10.2210/pdb5da3/pdb
• Descriptor: Protein-tyrosine kinase 6, GLYCEROL, (2-chloro-4-{[6-cyclopropyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone, ... (4 entities in total)
• Functional Keywords: ptk6, brk, complex, inhibitor, kinase, transferase, imidazo pyrazin, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: Q13882
• Total number of polymer chains: 1
• Total formula weight: 31236.44

Authors

Thakur, M.K.,Birudukota, S.,Swaminathan, S.,Battula, S.K.,Vadivelu, S.,Tyagi, R.,Gosu, R. (deposition date: 2015-08-19, release date: 2016-08-24, Last modification date: 2023-11-08)

• Primary citation: Thakur, M.K.,Birudukota, S.,Swaminathan, S.,Battula, S.K.,Vadivelu, S.,Tyagi, R.,Gosu, R.; Co-crystal structures of PTK6: With Dasatinib at 2.24 angstrom , with novel imidazo[1,2-a]pyrazin-8-amine derivative inhibitor at 1.70 angstrom resolution; Biochem. Biophys. Res. Commun., 482:1289-1295, 2017; PubMed: 27993680; DOI: 10.1016/j.bbrc.2016.12.030

Experimental method

X-RAY DIFFRACTION (1.7 Å)