5D8J

Development of a therapeutic monoclonal antibody targeting secreted aP2 to treat type 2 diabetes.

Summary for 5D8J

• Entry DOI: 10.2210/pdb5d8j/pdb
• Related: 5C0N
• Descriptor: Fatty acid-binding protein, adipocyte, HA3 Fab Heavy Chain, HA3 Fab Light Chain, ... (5 entities in total)
• Functional Keywords: ap2, fabp4, diabetes, metabolic syndrome, immune system
• Biological source: Mus musculus (House Mouse); More
• Cellular location: Cytoplasm: P04117
• Total number of polymer chains: 3
• Total formula weight: 62160.44

Authors

Doyle, C.,Birrane, G. (deposition date: 2015-08-17, release date: 2016-01-13, Last modification date: 2017-08-02)

• Primary citation: Burak, M.F.,Inouye, K.E.,White, A.,Lee, A.,Tuncman, G.,Calay, E.S.,Sekiya, M.,Tirosh, A.,Eguchi, K.,Birrane, G.,Lightwood, D.,Howells, L.,Odede, G.,Hailu, H.,West, S.,Garlish, R.,Neale, H.,Doyle, C.,Moore, A.,Hotamisligil, G.S.; Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes.; Sci Transl Med, 7:319ra205-319ra205, 2015; PubMed: 26702093; DOI: 10.1126/scitranslmed.aac6336

Experimental method

X-RAY DIFFRACTION (3 Å)