5D8I
Engineering the Species-Specificity of an Inhibitory Antibody Targeting a Modulator of Tumor Stroma
Summary for 5D8I
| Entry DOI | 10.2210/pdb5d8i/pdb |
| Related | 3Q6O |
| Descriptor | Sulfhydryl oxidase 1 (2 entities in total) |
| Functional Keywords | enzyme, disulfide bonds, thioredoxin fold, oxidoreductase |
| Biological source | Mus musculus (Mouse) |
| Cellular location | Isoform 1: Golgi apparatus membrane ; Single-pass membrane protein . Isoform 2: Secreted. Isoform 3: Secreted. Isoform 4: Secreted: Q8BND5 |
| Total number of polymer chains | 2 |
| Total formula weight | 53183.99 |
| Authors | Grossman, I.,Fass, D. (deposition date: 2015-08-17, release date: 2016-02-10, Last modification date: 2024-01-10) |
| Primary citation | Grossman, I.,Ilani, T.,Fleishman, S.J.,Fass, D. Overcoming a species-specificity barrier in development of an inhibitory antibody targeting a modulator of tumor stroma. Protein Eng.Des.Sel., 29:135-147, 2016 Cited by PubMed: 26819240DOI: 10.1093/protein/gzv067 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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