5D7Q

Crystal structure of human Sirt2 in complex with ADPR and CHIC35

Summary for 5D7Q

Entry DOI	10.2210/pdb5d7q/pdb
Descriptor	NAD-dependent protein deacetylase sirtuin-2, ZINC ION, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ... (5 entities in total)
Functional Keywords	hydrolase, human sirt2, inhibitor complex, deacylase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus. Isoform 1: Cytoplasm . Isoform 2: Cytoplasm . Isoform 5: Cytoplasm : Q8IXJ6
Total number of polymer chains	2
Total formula weight	71133.84
Authors	Rumpf, T.,Gerhardt, S.,Einsle, O.,Jung, M. (deposition date: 2015-08-14, release date: 2015-12-02, Last modification date: 2024-01-10)
Primary citation	Rumpf, T.,Gerhardt, S.,Einsle, O.,Jung, M. Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking. Acta Crystallogr.,Sect.F, 71:1498-1510, 2015 Cited by PubMed: 26625292 DOI: 10.1107/S2053230X15019986 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.01 Å)

Structure validation