5D3C
Crystal structure of a double mutant catalytic domain of Human MMP12 in complex with an hydroxamate analogue of RXP470
Summary for 5D3C
| Entry DOI | 10.2210/pdb5d3c/pdb |
| Descriptor | Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (5 entities in total) |
| Functional Keywords | mmp12, human, macrophage metalloelastase, rxp470, hydroxamate, hydrolase |
| Biological source | Homo sapiens (Human) |
| Cellular location | Secreted, extracellular space, extracellular matrix : P39900 |
| Total number of polymer chains | 1 |
| Total formula weight | 18466.68 |
| Authors | Rouanet-Mehouas, C.,Devel, L.,Dive, V.,Stura, E.A. (deposition date: 2015-08-06, release date: 2016-08-17, Last modification date: 2024-01-10) |
| Primary citation | Rouanet-Mehouas, C.,Czarny, B.,Beau, F.,Cassar-Lajeunesse, E.,Stura, E.A.,Dive, V.,Devel, L. Zinc-Metalloproteinase Inhibitors: Evaluation of the Complex Role Played by the Zinc-Binding Group on Potency and Selectivity. J. Med. Chem., 60:403-414, 2017 Cited by PubMed: 27996256DOI: 10.1021/acs.jmedchem.6b01420 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.314 Å) |
Structure validation
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