5D25
First bromodomain of BRD4 bound to inhibitor XD27
Summary for 5D25
| Entry DOI | 10.2210/pdb5d25/pdb |
| Descriptor | Bromodomain-containing protein 4, 4-acetyl-N-[5-(diethylsulfamoyl)-2-hydroxyphenyl]-3,5-dimethyl-1H-pyrrole-2-carboxamide, GLYCEROL, ... (5 entities in total) |
| Functional Keywords | gene regulation, inhibitor, bromodomain, transcription |
| Biological source | Homo sapiens (Human) |
| Cellular location | Nucleus: O60885 |
| Total number of polymer chains | 1 |
| Total formula weight | 15602.00 |
| Authors | Wohlwend, D.,Huegle, M.,Gerhardt, S. (deposition date: 2015-08-05, release date: 2016-01-20, Last modification date: 2017-09-06) |
| Primary citation | Hugle, M.,Lucas, X.,Weitzel, G.,Ostrovskyi, D.,Breit, B.,Gerhardt, S.,Einsle, O.,Gunther, S.,Wohlwend, D. 4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1). J.Med.Chem., 59:1518-1530, 2016 Cited by PubMed: 26731611DOI: 10.1021/acs.jmedchem.5b01267 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
Download full validation report
