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5D1B

Crystal structure of G117E HDAC8 in complex with TSA

Summary for 5D1B
Entry DOI10.2210/pdb5d1b/pdb
Related5D1C 5D1D
DescriptorHistone deacetylase 8, ZINC ION, POTASSIUM ION, ... (5 entities in total)
Functional Keywordshydrolase, histone deacetylase, arginase/deacetylase fold, enzyme inhibitor complex
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight87500.05
Authors
Decroos, C.,Christianson, N.H.,Gullett, L.E.,Bowman, C.M.,Christianson, K.E.,Deardorff, M.A.,Christianson, D.W. (deposition date: 2015-08-04, release date: 2015-10-21, Last modification date: 2023-09-27)
Primary citationDecroos, C.,Christianson, N.H.,Gullett, L.E.,Bowman, C.M.,Christianson, K.E.,Deardorff, M.A.,Christianson, D.W.
Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders.
Biochemistry, 54:6501-6513, 2015
Cited by
PubMed: 26463496
DOI: 10.1021/acs.biochem.5b00881
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.9 Å)
Structure validation

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