5CUH
Crystal structure MMP-9 complexes with a constrained hydroxamate based inhibitor LT4
Summary for 5CUH
| Entry DOI | 10.2210/pdb5cuh/pdb |
| Descriptor | Matrix metalloproteinase-9,Matrix metalloproteinase-9, ZINC ION, CALCIUM ION, ... (8 entities in total) |
| Functional Keywords | mmp-9 hydroxamate-based inhibitor gelatinase, hydrolase |
| Biological source | Homo sapiens (Human) |
| Cellular location | Secreted, extracellular space, extracellular matrix : P14780 |
| Total number of polymer chains | 2 |
| Total formula weight | 38480.33 |
| Authors | Tepshi, L.,Vera, L.,Nuti, E.,Rosalia, L.,Rossello, A.,Stura, E.A. (deposition date: 2015-07-24, release date: 2016-02-10, Last modification date: 2023-11-08) |
| Primary citation | Camodeca, C.,Nuti, E.,Tepshi, L.,Boero, S.,Tuccinardi, T.,Stura, E.A.,Poggi, A.,Zocchi, M.R.,Rossello, A. Discovery of a new selective inhibitor of A Disintegrin And Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin's lymphoma cell models. Eur.J.Med.Chem., 111:193-201, 2016 Cited by PubMed: 26871660DOI: 10.1016/j.ejmech.2016.01.053 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.83 Å) |
Structure validation
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