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5CTY

Crystal structure of the ATP binding domain of S. aureus GyrB complexed with a fragment

Summary for 5CTY
Entry DOI10.2210/pdb5cty/pdb
Related5CPH 5CTU 5CTW 5CTX
DescriptorDNA gyrase subunit B, (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, ... (6 entities in total)
Functional Keywordsdna gyrase, gyrb, fragment-based screening, structure-based design, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
Biological sourceStaphylococcus aureus
Cellular locationCytoplasm : P0A0K8
Total number of polymer chains2
Total formula weight48868.91
Authors
Andersen, O.A.,Barker, J.,Cheng, R.K.,Kahmann, J.,Felicetti, B.,Wood, M.,Scheich, C.,Mesleh, M.,Cross, J.B.,Zhang, J.,Yang, Q.,Lippa, B.,Ryan, M.D. (deposition date: 2015-07-24, release date: 2016-02-03, Last modification date: 2023-09-27)
Primary citationMesleh, M.F.,Cross, J.B.,Zhang, J.,Kahmann, J.,Andersen, O.A.,Barker, J.,Cheng, R.K.,Felicetti, B.,Wood, M.,Hadfield, A.T.,Scheich, C.,Moy, T.I.,Yang, Q.,Shotwell, J.,Nguyen, K.,Lippa, B.,Dolle, R.,Ryan, M.D.
Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB.
Bioorg.Med.Chem.Lett., 26:1314-1318, 2016
Cited by
PubMed: 26786695
DOI: 10.1016/j.bmcl.2016.01.009
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.6 Å)
Structure validation

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