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5CSX

CRYSTAL STRUCTURE OF B-RAF IN COMPLEX WITH BI 882370

Summary for 5CSX
Entry DOI10.2210/pdb5csx/pdb
DescriptorSerine/threonine-protein kinase B-raf, N-(3-{5-[(1-ethylpiperidin-4-yl)(methyl)amino]-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl}-2,4-difluorophenyl)propane-1-sulfonamide, alpha-D-glucopyranose, ... (4 entities in total)
Functional Keywordskinase, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight32779.52
Authors
Bader, G.,Stadtmuller, H.,Steurer, S. (deposition date: 2015-07-23, release date: 2016-03-09, Last modification date: 2024-01-10)
Primary citationWaizenegger, I.C.,Baum, A.,Steurer, S.,Stadtmuller, H.,Bader, G.,Schaaf, O.,Garin-Chesa, P.,Schlattl, A.,Schweifer, N.,Haslinger, C.,Colbatzky, F.,Mousa, S.,Kalkuhl, A.,Kraut, N.,Adolf, G.R.
A Novel RAF Kinase Inhibitor with DFG-Out-Binding Mode: High Efficacy in BRAF-Mutant Tumor Xenograft Models in the Absence of Normal Tissue Hyperproliferation.
Mol.Cancer Ther., 15:354-365, 2016
Cited by
PubMed: 26916115
DOI: 10.1158/1535-7163.MCT-15-0617
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.51 Å)
Structure validation

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