5CRF

Structure of the penicillin-binding protein PonA1 from Mycobacterium Tuberculosis

Summary for 5CRF

• Entry DOI: 10.2210/pdb5crf/pdb
• Related: 5CXW
• Descriptor: Penicillin-binding protein 1A, PHOSPHATE ION (3 entities in total)
• Functional Keywords: b-lactam, pbp, structural genomics, psi-biology, midwest center for structural genomics, mcsg, structures of mtb proteins conferring susceptibility to known mtb inhibitors, mtbi, penicillin-binding protein
• Biological source: Mycobacterium tuberculosis
• Cellular location: Cell membrane ; Single-pass membrane protein : P71707
• Total number of polymer chains: 4
• Total formula weight: 179025.28

Authors

Filippova, E.V.,Wawrzak, Z.,Kiryukhina, O.,Kieser, K.,Endres, M.,Rubin, E.,Sacchettini, J.,Joachimiak, A.,Anderson, W.F.,Midwest Center for Structural Genomics (MCSG),Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI) (deposition date: 2015-07-22, release date: 2016-05-04, Last modification date: 2016-07-06)

• Primary citation: Filippova, E.V.,Kieser, K.J.,Luan, C.H.,Wawrzak, Z.,Kiryukhina, O.,Rubin, E.J.,Anderson, W.F.; Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance.; Febs J., 283:2206-2218, 2016; PubMed: 27101811; DOI: 10.1111/febs.13738

Experimental method

X-RAY DIFFRACTION (1.8 Å)