5CQ2

Crystal Structure of tandem WW domains of ITCH in complex with TXNIP peptide

Replaces:  4ROH

Summary for 5CQ2

• Entry DOI: 10.2210/pdb5cq2/pdb
• Descriptor: E3 ubiquitin-protein ligase Itchy homolog, Thioredoxin-interacting protein, UNKNOWN ATOM OR ION, ... (4 entities in total)
• Functional Keywords: structural genomics, structural genomics consortium, sgc, ligase
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane: Q96J02; Cytoplasm : Q9H3M7
• Total number of polymer chains: 3
• Total formula weight: 13131.59

Authors

Liu, Y.,Tempel, W.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Min, J.,Structural Genomics Consortium (SGC) (deposition date: 2015-07-21, release date: 2015-09-16, Last modification date: 2023-09-27)

• Primary citation: Liu, Y.,Lau, J.,Li, W.,Tempel, W.,Li, L.,Dong, A.,Narula, A.,Qin, S.,Min, J.; Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP.; Biochem.J., 473:179-187, 2016; PubMed: 26527736; DOI: 10.1042/BJ20150830

Experimental method

X-RAY DIFFRACTION (1.4 Å)