5CMX
X-ray structure of the complex between human alpha thrombin and a duplex/quadruplex 31-mer DNA aptamer
Summary for 5CMX
Entry DOI | 10.2210/pdb5cmx/pdb |
Related | 3QLP 4DIH 4DII 4I7Y 4LZ1 4LZ4 |
Related PRD ID | PRD_000020 |
Descriptor | alpha thrombin-light chain, Thrombin heavy chain, RE31, ... (6 entities in total) |
Functional Keywords | dna aptamer, duplex/g-quadruplex fold, thrombin, exosite i, hydrolase |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 |
Total number of polymer chains | 3 |
Total formula weight | 44097.05 |
Authors | Russo Krauss, I.,Pica, A.,Napolitano, V.,Sica, F. (deposition date: 2015-07-17, release date: 2016-01-13, Last modification date: 2024-01-10) |
Primary citation | Russo Krauss, I.,Spiridonova, V.,Pica, A.,Napolitano, V.,Sica, F. Different duplex/quadruplex junctions determine the properties of anti-thrombin aptamers with mixed folding. Nucleic Acids Res., 44:983-991, 2016 Cited by PubMed: 26673709DOI: 10.1093/nar/gkv1384 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.98 Å) |
Structure validation
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