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5CMX

X-ray structure of the complex between human alpha thrombin and a duplex/quadruplex 31-mer DNA aptamer

Summary for 5CMX
Entry DOI10.2210/pdb5cmx/pdb
Related3QLP 4DIH 4DII 4I7Y 4LZ1 4LZ4
Related PRD IDPRD_000020
Descriptoralpha thrombin-light chain, Thrombin heavy chain, RE31, ... (6 entities in total)
Functional Keywordsdna aptamer, duplex/g-quadruplex fold, thrombin, exosite i, hydrolase
Biological sourceHomo sapiens (Human)
More
Cellular locationSecreted, extracellular space: P00734 P00734
Total number of polymer chains3
Total formula weight44097.05
Authors
Russo Krauss, I.,Pica, A.,Napolitano, V.,Sica, F. (deposition date: 2015-07-17, release date: 2016-01-13, Last modification date: 2024-01-10)
Primary citationRusso Krauss, I.,Spiridonova, V.,Pica, A.,Napolitano, V.,Sica, F.
Different duplex/quadruplex junctions determine the properties of anti-thrombin aptamers with mixed folding.
Nucleic Acids Res., 44:983-991, 2016
Cited by
PubMed: 26673709
DOI: 10.1093/nar/gkv1384
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.98 Å)
Structure validation

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