5CHP

T. maritima ThyX in complex with TyC5-03

5CHP の概要

• エントリーDOI: 10.2210/pdb5chp/pdb
• 分子名称: Thymidylate synthase ThyX, FLAVIN-ADENINE DINUCLEOTIDE, (2S)-2-[(3-hydroxy-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)sulfanyl]propanoic acid, ... (4 entities in total)
• 機能のキーワード: thyx in complex with inhibitor, hydrolase
• 由来する生物種: Thermotoga maritima
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28780.75

構造登録者

Surade, S.,Luciani, R.,Saxena, P.,Santucci, M.,Ferrari, S.,Venturelli, A.,Marverti, G.,Ponterini, G.,Abell, C.A.,Blundell, T.L.,Costi, M.P. (登録日: 2015-07-10, 公開日: 2016-10-19, 最終更新日: 2024-01-10)

• 主引用文献: Surade, S.; Identification of inhibitors targeting substrate-binding site in Mycobacterium tuberculosis FAD-dependent Thymidylate synthase (ThyX) through Virtual Screening: A New study de-fining the binding mechanism of Inhibitors; To Be Published,

実験手法

X-RAY DIFFRACTION (1.7 Å)