5C7K

Crystal structure BG505 SOSIP gp140 HIV-1 Env trimer bound to broadly neutralizing antibodies PGT128 and 8ANC195

Summary for 5C7K

• Entry DOI: 10.2210/pdb5c7k/pdb
• Descriptor: Antibody Fab PGT128 heavy chain, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (16 entities in total)
• Functional Keywords: hiv-1, sosip, pgt128, 8anc195, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 6
• Total formula weight: 183365.48

Authors

Kong, L.,Stanfield, R.L.,Wilson, I.A. (deposition date: 2015-06-24, release date: 2015-10-07, Last modification date: 2023-09-27)

• Primary citation: Kong, L.,Torrents de la Pena, A.,Deller, M.C.,Garces, F.,Sliepen, K.,Hua, Y.,Stanfield, R.L.,Sanders, R.W.,Wilson, I.A.; Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer.; Acta Crystallogr.,Sect.D, 71:2099-2108, 2015; PubMed: 26457433; DOI: 10.1107/S1399004715013917

Experimental method

X-RAY DIFFRACTION (4.6019 Å)