5C53

Probing the Structural and Molecular Basis of Nucleotide Selectivity by Human Mitochondrial DNA Polymerase gamma

Summary for 5C53

• Entry DOI: 10.2210/pdb5c53/pdb
• Related: 5C52
• Descriptor: DNA polymerase subunit gamma-1, Pol gamma B, DNA (26-MER), ... (7 entities in total)
• Functional Keywords: nucleoside reverse transcriptase inhibitors (nrtis), hiv reverse transcriptase (rt), human mitochondrial dna polymerase, mitochondrial toxicity, drug efficacy and toxicity, transferase, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (Human); More
• Cellular location: Mitochondrion : P54098
• Total number of polymer chains: 5
• Total formula weight: 356486.26

Authors

Sohl, C.D.,Szymanski, M.R.,Mislak, A.C.,Shumate, C.K.,Amiralaei, S.,Schinazi, R.F.,Anderson, K.S.,Yin, Y.W. (deposition date: 2015-06-19, release date: 2016-01-27, Last modification date: 2024-03-06)

• Primary citation: Sohl, C.D.,Szymanski, M.R.,Mislak, A.C.,Shumate, C.K.,Amiralaei, S.,Schinazi, R.F.,Anderson, K.S.,Yin, Y.W.; Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase gamma.; Proc.Natl.Acad.Sci.USA, 112:8596-8601, 2015; PubMed: 26124101; DOI: 10.1073/pnas.1421733112

Experimental method

X-RAY DIFFRACTION (3.567 Å)