5C4T

Identification of a Novel Allosteric Binding Site for RORgt Inhibitors

Summary for 5C4T

Entry DOI	10.2210/pdb5c4t/pdb
Related	5C4O 5C4S 5C4U
Descriptor	Nuclear receptor ROR-gamma, (1S)-4-{1-[2-chloro-6-(trifluoromethyl)benzoyl]-4-fluoro-1H-indazol-3-yl}-1-methylcyclohex-3-ene-1-carboxylic acid, SULFATE ION, ... (5 entities in total)
Functional Keywords	allosteric, inhibitor, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : P51449
Total number of polymer chains	1
Total formula weight	29502.29
Authors	Parthasarathy, G.,Soisson, S. (deposition date: 2015-06-18, release date: 2015-12-16, Last modification date: 2024-03-06)
Primary citation	Scheepstra, M.,Leysen, S.,van Almen, G.C.,Miller, J.R.,Piesvaux, J.,Kutilek, V.,van Eenennaam, H.,Zhang, H.,Barr, K.,Nagpal, S.,Soisson, S.M.,Kornienko, M.,Wiley, K.,Elsen, N.,Sharma, S.,Correll, C.C.,Trotter, B.W.,van der Stelt, M.,Oubrie, A.,Ottmann, C.,Parthasarathy, G.,Brunsveld, L. Identification of an allosteric binding site for ROR gamma t inhibition. Nat Commun, 6:8833-8833, 2015 Cited by PubMed: 26640126 DOI: 10.1038/ncomms9833 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.77 Å)

Structure validation