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5C2H

PDE10 complexed with 6-chloro-N-[(2,4-dimethylthiazol-5-yl)methyl]-5-methyl-2-[3-(2-quinolyl)propoxy]pyrimidin-4-amine

Summary for 5C2H
Entry DOI10.2210/pdb5c2h/pdb
Related5C1W 5C28 5C29 5C2A 5C2E
DescriptorcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (6 entities in total)
Functional Keywordsphosphodiesterase, inhibitor, complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: Q9Y233
Total number of polymer chains2
Total formula weight83974.79
Authors
Yan, Y. (deposition date: 2015-06-15, release date: 2015-10-07, Last modification date: 2024-03-13)
Primary citationShipe, W.D.,Sharik, S.S.,Barrow, J.C.,McGaughey, G.B.,Theberge, C.R.,Uslaner, J.M.,Yan, Y.,Renger, J.J.,Smith, S.M.,Coleman, P.J.,Cox, C.D.
Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis.
J.Med.Chem., 58:7888-7894, 2015
Cited by
PubMed: 26378882
DOI: 10.1021/acs.jmedchem.5b00983
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.09 Å)
Structure validation

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