5BZX

Crystal structure of human phosphatase PTEN treated with a bisperoxovanadium complex

5BZX の概要

• エントリーDOI: 10.2210/pdb5bzx/pdb
• 分子名称: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, VANADATE ION, L(+)-TARTARIC ACID, ... (4 entities in total)
• 機能のキーワード: phosphatase, c2 domain, disulfide, oxidized, vanadate, hydrolase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm. Isoform alpha: Secreted : P60484
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 149911.36

構造登録者

Lee, C.-U.,Bier, D.,Hennig, S.,Grossmann, T.N. (登録日: 2015-06-11, 公開日: 2015-10-07, 最終更新日: 2024-01-10)

• 主引用文献: Lee, C.U.,Hahne, G.,Hanske, J.,Bange, T.,Bier, D.,Rademacher, C.,Hennig, S.,Grossmann, T.N.; Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes.; Angew.Chem.Int.Ed.Engl., 54:13796-13800, 2015; PubMed: 26418532; DOI: 10.1002/anie.201506338

実験手法

X-RAY DIFFRACTION (2.5 Å)