5BTR

Crystal structure of SIRT1 in complex with resveratrol and an AMC-containing peptide

Summary for 5BTR

• Entry DOI: 10.2210/pdb5btr/pdb
• Descriptor: NAD-dependent protein deacetylase sirtuin-1, AMC-containing peptide, ZINC ION, ... (5 entities in total)
• Functional Keywords: deacetylase, human sirtuin 1, n-terminal domain, catalytic domain, c-terminal domain, resveratrol, substrate, hydrolase-substrate complex, hydrolase/substrate
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus, PML body . SirtT1 75 kDa fragment: Cytoplasm : Q96EB6
• Total number of polymer chains: 6
• Total formula weight: 139759.39

Authors

Cao, D.,Wang, M.,Qiu, X.,Liu, D.,Jiang, H.,Yang, N.,Xu, R.M. (deposition date: 2015-06-03, release date: 2015-07-08, Last modification date: 2023-11-08)

• Primary citation: Cao, D.,Wang, M.,Qiu, X.,Liu, D.,Jiang, H.,Yang, N.,Xu, R.M.; Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol; Genes Dev., 29:1316-1325, 2015; PubMed: 26109052; DOI: 10.1101/gad.265462.115

Experimental method

X-RAY DIFFRACTION (3.2 Å)