5BRZ

MAGE-A3 reactive TCR in complex with MAGE-A3 in HLA-A1

Summary for 5BRZ

• Entry DOI: 10.2210/pdb5brz/pdb
• Related: 5BS0
• Descriptor: HLA class I histocompatibility antigen, A-1 alpha chain, Beta-2-microglobulin, GLU-VAL-ASP-PRO-ILE-GLY-HIS-LEU-TYR, ... (7 entities in total)
• Functional Keywords: immuno pmhc tcr mage, immune system
• Biological source: Homo sapiens (Human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P30443; Secreted : P61769; Membrane ; Single-pass membrane protein : P01848
• Total number of polymer chains: 5
• Total formula weight: 93912.98

Authors

Raman, M.C.C.,Rizkallah, P.J.,Simmons, R.,Donnellan, Z.,Dukes, J.,Bossi, G.,LeProvost, G.,Mahon, T.,Hickman, E.,LomaX, M.,Oates, J.,Hassan, N.,Vuidepot, A.,Sami, M.,Cole, D.K.,Jakobsen, B.K. (deposition date: 2015-06-01, release date: 2016-03-02, Last modification date: 2024-01-10)

• Primary citation: Raman, M.C.,Rizkallah, P.J.,Simmons, R.,Donnellan, Z.,Dukes, J.,Bossi, G.,Le Provost, G.S.,Todorov, P.,Baston, E.,Hickman, E.,Mahon, T.,Hassan, N.,Vuidepot, A.,Sami, M.,Cole, D.K.,Jakobsen, B.K.; Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.; Sci Rep, 6:18851-18851, 2016; PubMed: 26758806; DOI: 10.1038/srep18851

Experimental method

X-RAY DIFFRACTION (2.62 Å)