5BNE
Bianthranilate-like inhibitor with 6 atom "line" and phosphonate "hook" fishing for hydrogen bond donors in Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD)
Summary for 5BNE
Entry DOI | 10.2210/pdb5bne/pdb |
Related | 3QR9 4IJ1 |
Descriptor | Anthranilate phosphoribosyltransferase, 2-[(2-carboxyphenyl)amino]-5-[(5-phosphonopentyl)oxy]benzoic acid, IMIDAZOLE, ... (4 entities in total) |
Functional Keywords | inhibitor, complex, lobenzarit-like analogue, trpd, anprt, tb structural genomics consortium, tbsgc, phosphoribosyltransferase, magnesium binding, phosphoribosylpyrophosphate, prpp, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 4 |
Total formula weight | 157338.45 |
Authors | Evans, G.L.,Baker, E.N.,Lott, J.S.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2015-05-26, release date: 2016-05-25, Last modification date: 2023-09-27) |
Primary citation | Evans, G.L.,Baker, E.N.,Lott, J.S. Binding and mimicking of the phosphate-rich substrate, PRPP. To be Published, |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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