5B2L

A crucial role of Cys218 in the stabilization of an unprecedented auto-inhibition form of MAP2K7

Summary for 5B2L

Entry DOI	10.2210/pdb5b2l/pdb
Related	5B2K 5B2M
Descriptor	Dual specificity mitogen-activated protein kinase kinase 7, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, ... (4 entities in total)
Functional Keywords	protein kinase, mutation, apo structure, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	37551.54
Authors	Sogabe, Y.,Hashimoto, T.,Matsumoto, T.,Kirii, Y.,Sawa, M.,Kinoshita, T. (deposition date: 2016-01-19, release date: 2016-04-06, Last modification date: 2023-11-08)
Primary citation	Sogabe, Y.,Hashimoto, T.,Matsumoto, T.,Kirii, Y.,Sawa, M.,Kinoshita, T. A crucial role of Cys218 in configuring an unprecedented auto-inhibition form of MAP2K7 Biochem.Biophys.Res.Commun., 473:476-481, 2016 Cited by PubMed: 26987717 DOI: 10.1016/j.bbrc.2016.03.036 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation