5AWA

Crystal structure of human TLR8 in complex with MB-568

Summary for 5AWA

• Entry DOI: 10.2210/pdb5awa/pdb
• Related: 5AWB 5AWC 5AWD
• Descriptor: Toll-like receptor 8, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: immune system, tlr8, adjuvant, vaccine adjuvants, linnate immunity, glycosylation
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 96417.85

Authors

Tanji, H.,Ohto, U.,Shimizu, T. (deposition date: 2015-07-03, release date: 2016-07-20, Last modification date: 2020-07-29)

• Primary citation: Beesu, M.,Caruso, G.,Salyer, A.C.D.,Khetani, K.K.,Sil, D.,Weerasinghe, M.,Tanji, H.,Ohto, U.,Shimizu, T.,David, S.A.; Structure-based Design of Human TLR8-specific Agonists with Augmented Potency and Adjuvanticity; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)