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5AQM

Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues

Summary for 5AQM
Entry DOI10.2210/pdb5aqm/pdb
Related5AQF 5AQG 5AQH 5AQI 5AQJ 5AQK 5AQL 5AQN 5AQO 5AQP 5AQQ 5AQR 5AQS 5AQT 5AQU 5AQV 5AQW 5AQX 5AQY 5AQZ 5AR0
DescriptorHEAT SHOCK COGNATE 71 KDA PROTEIN, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (5 entities in total)
Functional Keywordsheat shock protein, hsp70, hsp72, hsc70, atpase, bag1, chaperone, fragment
Biological sourceHOMO SAPIENS (HUMAN)
More
Cellular locationCytoplasm: P11142
Isoform 1: Nucleus. Isoform 2: Cytoplasm. Isoform 4: Cytoplasm: Q99933
Total number of polymer chains4
Total formula weight112998.43
Authors
Primary citationJones, A.M.,Westwood, I.M.,Osborne, J.D.,Matthews, T.P.,Cheeseman, M.D.,Rowlands, M.G.,Jeganathan, F.,Burke, R.,Lee, D.,Kadi, N.,Liu, M.,Richards, M.,McAndrew, C.,Yahya, N.,Dobson, S.E.,Jones, K.,Workman, P.,Collins, I.,van Montfort, R.L.
A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep, 6:34701-34701, 2016
Cited by
PubMed: 27708405
DOI: 10.1038/srep34701
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.63 Å)
Structure validation

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