5AOM

Structure of the p53 cancer mutant Y220C with bound small molecule PhiKan883

Summary for 5AOM

• Entry DOI: 10.2210/pdb5aom/pdb
• Related: 5AOI 5AOJ 5AOK 5AOL
• Descriptor: CELLULAR TUMOR ANTIGEN P53, N-(5-chloranyl-2-oxidanyl-phenyl)piperidine-4-carboxamide, GLYCEROL, ... (5 entities in total)
• Functional Keywords: cell cycle, p53, cancer, tumor suppression, dna binding, cancer therapy, small-molecule stabilizers, molecular chaperone
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 50303.39

Authors

Joerger, A.C.,Boeckler, F.M.,Wilcken, R. (deposition date: 2015-09-10, release date: 2015-12-16, Last modification date: 2024-01-10)

• Primary citation: Joerger, A.C.,Bauer, M.R.,Wilcken, R.,Baud, M.G.J.,Harbrecht, H.,Exner, T.E.,Boeckler, F.M.,Spencer, J.,Fersht, A.R.; Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53.; Structure, 23:2246-, 2015; PubMed: 26636255; DOI: 10.1016/J.STR.2015.10.016

Experimental method

X-RAY DIFFRACTION (1.74 Å)