5AKS

Transthyretin binding heterogeneity and anti-amyloidogenic activity of natural polyphenols and their metabolites: resveratrol-3-O- glucuronide

Summary for 5AKS

Entry DOI	10.2210/pdb5aks/pdb
Related	5AKT 5AKV 5AL0 5AL8
Descriptor	TRANSTHYRETIN, SULFATE ION, Resveratrol-3-O-glucuronide, ... (5 entities in total)
Functional Keywords	transport protein, amyloid, fibrillogenesis, fibrillogenesis inhibitors, polyphenols, polyphenol metabolites, transthyretin, negative cooperativity
Biological source	Homo sapiens (HUMAN)
Total number of polymer chains	2
Total formula weight	28633.71
Authors	Florio, P.,Foll, C.,Cianci, M.,Del Rio, D.,Zanotti, G.,Berni, R. (deposition date: 2015-03-05, release date: 2015-10-21, Last modification date: 2024-01-10)
Primary citation	Florio, P.,Folli, C.,Cianci, M.,Del Rio, D.,Zanotti, G.,Berni, R. Transthyretin Binding Heterogeneity and Anti-Amyloidogenic Activity of Natural Polyphenols and Their Metabolites J.Biol.Chem., 290:29769-, 2015 Cited by PubMed: 26468275 DOI: 10.1074/JBC.M115.690172 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.25 Å)

Structure validation