5AGE

CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A BENZOMORPHOLINONE LIGAND

Summary for 5AGE

• Entry DOI: 10.2210/pdb5age/pdb
• Related: 5AG4 5AG5 5AG6 5AG7
• Descriptor: GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, 4-[(5-methyl-1,2-oxazol-3-yl)methyl]-7-[4-(1-methylpiperidin-4-yl)butyl]-2H-1,4-benzoxazin-3(4H)-one, TETRADECANOYL-COA, ... (4 entities in total)
• Functional Keywords: nmt, acyltransferase, transferase, drug discovery
• Biological source: LEISHMANIA MAJOR
• Total number of polymer chains: 1
• Total formula weight: 51888.65

Authors

Robinson, D.A.,Spinks, D.,Smith, V.C.,Thompson, S.,Smith, A.,Torrie, L.S.,McElroy, S.P.,Brand, S.,Brenk, R.,Frearson, J.A.,Read, K.D.,Wyatt, P.G.,Gilbert, I.H. (deposition date: 2015-01-29, release date: 2015-10-07, Last modification date: 2024-01-10)

• Primary citation: Spinks, D.,Smith, V.,Thompson, S.,Robinson, D.A.,Luksch, T.,Smith, A.,Torrie, L.S.,Mcelroy, S.,Stojanovski, L.,Norval, S.,Collie, I.T.,Hallyburton, I.,Rao, B.,Brand, S.,Brenk, R.,Frearson, J.A.,Read, K.D.,Wyatt, P.G.,Gilbert, I.H.; Development of Small-Molecule Trypanosoma Brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode.; Chemmedchem, 10:1821-, 2015; PubMed: 26395087; DOI: 10.1002/CMDC.201500301

Experimental method

X-RAY DIFFRACTION (2 Å)