5ABW

Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases

Summary for 5ABW

Entry DOI	10.2210/pdb5abw/pdb
Descriptor	NEUTROPHIL ELASTASE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 1-(3-CHLOROPHENYL)-5-(3,5-DIMETHYLISOXAZOL-4-YL)-6-METHYL-N-[4-(METHYLSULFONYL)BENZYL]-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE, ... (5 entities in total)
Functional Keywords	trypsin family fold, protease, hydrolase, hydrolase-inhibitor complex
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	24521.89
Authors	von Nussbaum, F.,Li, V.M.,Schaefer, M. (deposition date: 2015-08-10, release date: 2015-08-19, Last modification date: 2020-07-29)
Primary citation	von Nussbaum, F.,Li, V.M. Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: Into clinical testing with pre-adaptive pharmacophores. Bioorg. Med. Chem. Lett., 25:4370-4381, 2015 Cited by PubMed: 26358162 DOI: 10.1016/j.bmcl.2015.08.049 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation