5ABG

Structure of GH84 with ligand

Summary for 5ABG

Entry DOI	10.2210/pdb5abg/pdb
Related	5ABE 5ABF 5ABH
Descriptor	O-GLCNACASE BT_4395, 1,2-ETHANEDIOL, 2-[(2R,3S,4R,5R)-1-[3-(4-fluorophenyl)propyl]-5-(hydroxymethyl)-3,4-bis(oxidanyl)pyrrolidin-2-yl]-N-methyl-ethanamide, ... (5 entities in total)
Functional Keywords	hydrolase, gh84 glycoside hydrolase, tim-barrel, inhibitor
Biological source	BACTEROIDES THETAIOTAOMICRON
Total number of polymer chains	2
Total formula weight	167859.79
Authors	Bergeron-Brlek, M.,Goodwin-Tindall, J.,Cekic, N.,Varghese, V.,Zandberg, W.F.,Shan, X.,Roth, C.,Chan, S.,Davies, G.J.,Vocadlo, D.J.,Britton, R. (deposition date: 2015-08-05, release date: 2015-11-18, Last modification date: 2019-10-23)
Primary citation	Bergeron-Brlek, M.,Goodwin-Tindall, J.,Cekic, N.,Roth, C.,Zandberg, W.F.,Shan, X.,Varghese, V.,Chan, S.,Davies, G.J.,Vocadlo, D.J.,Britton, R. A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable Oga Inhibitors. Angew.Chem.Int.Ed.Engl., 54:15429-, 2015 Cited by PubMed: 26545827 DOI: 10.1002/ANIE.201507985 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation