5A7J

Crystal structure of INPP5B in complex with benzene 1,2,4,5- tetrakisphosphate

Summary for 5A7J

• Entry DOI: 10.2210/pdb5a7j/pdb
• Related: 5A7I
• Descriptor: TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE, SULFATE ION, (2,4,5-triphosphonooxyphenyl) dihydrogen phosphate, ... (5 entities in total)
• Functional Keywords: hydrolase, sgc, signalling, structural genomics consortium stockholm, magnesium binding, protein-inhbitor complex, inhibitor, phosphoinositides signalling
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 73802.58

Authors

Tresaugues, L.,Mills, S.J.,Silvander, C.,Cozier, G.,Potter, B.V.L.,Nordlund, P. (deposition date: 2015-07-06, release date: 2016-04-13, Last modification date: 2024-01-10)

• Primary citation: Mills, S.J.,Silvander, C.,Cozier, G.,Tresaugues, L.,Nordlund, P.,Potter, B.V.L.; Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase Inpp5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.; Biochemistry, 55:1384-, 2016; PubMed: 26854536; DOI: 10.1021/ACS.BIOCHEM.5B00838

Experimental method

X-RAY DIFFRACTION (2.9 Å)