5A7I

Crystal structure of INPP5B in complex with biphenyl 3,3',4,4',5,5'- hexakisphosphate

Summary for 5A7I

• Entry DOI: 10.2210/pdb5a7i/pdb
• Related: 5A7J
• Descriptor: TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE, GLYCEROL, Biphenyl 3,3',4,4',5,5'-hexakisphosphate, ... (7 entities in total)
• Functional Keywords: hydrolase, sgc, signalling, structural genomics consortium stockholm, magnesium binding, protein-inhbitor complex, inhibitor, phosphoinositides signalling
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm, cytosol : P32019
• Total number of polymer chains: 1
• Total formula weight: 37367.94

Authors

Tresaugues, L.,Mills, S.J.,Silvander, C.,Cozier, G.,Potter, B.V.L.,Norldund, P. (deposition date: 2015-07-06, release date: 2016-04-13, Last modification date: 2024-01-10)

• Primary citation: Mills, S.J.,Silvander, C.,Cozier, G.,Tresaugues, L.,Nordlund, P.,Potter, B.V.L.; Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase Inpp5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.; Biochemistry, 55:1384-, 2016; PubMed: 26854536; DOI: 10.1021/ACS.BIOCHEM.5B00838

Experimental method

X-RAY DIFFRACTION (2.89 Å)