5A7B

Structure of the p53 cancer Y220C bound to the stabilizing small molecule PhiKan5211

Summary for 5A7B

• Entry DOI: 10.2210/pdb5a7b/pdb
• Descriptor: CELLULAR TUMOR ANTIGEN P53, ZINC ION, 2-[[4-(diethylamino)piperidin-1-yl]methyl]-6-ethynyl-4-(3-phenoxyprop-1-ynyl)phenol, ... (4 entities in total)
• Functional Keywords: antitumor protein, cancer, tumor suppression, ethynyl, dna binding, cancer therapy, small molecule stabilizers, molecular chaperone
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 50025.55

Authors

Joerger, A.C. (deposition date: 2015-07-03, release date: 2015-09-30, Last modification date: 2024-01-10)

• Primary citation: Wilcken, R.,Zimmermann, M.O.,Bauer, M.R.,Rutherford, T.J.,Fersht, A.R.,Joerger, A.C.,Boeckler, F.M.; Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere.; Acs Chem.Biol., 10:2725-, 2015; PubMed: 26378745; DOI: 10.1021/ACSCHEMBIO.5B00515

Experimental method

X-RAY DIFFRACTION (1.4 Å)