5A5Q

Crystal structure of human ATAD2 bromodomain in complex with 3-methyl- 8-piperidin-4-ylamino-1,2-dihydro-1,7-naphthyridin-2-one hydrochloride

Summary for 5A5Q

Entry DOI	10.2210/pdb5a5q/pdb
Related	5A5N 5A5O 5A5P 5A5R 5A5S
Descriptor	ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 2, 1,2-ETHANEDIOL, 3-methyl-8-[(piperidin-4-yl)amino]-1,2-dihydro-1,7-naphthyridin-2-one, ... (5 entities in total)
Functional Keywords	hydrolase, inhibitor, atad2, bromodomain, epigenetics, atpase family aaa domain-containing protein 2
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus : Q6PL18
Total number of polymer chains	1
Total formula weight	16028.09
Authors	Chung, C.,Bamborough, P.,Demont, E. (deposition date: 2015-06-20, release date: 2015-07-22, Last modification date: 2015-08-05)
Primary citation	Demont, E.H.,Chung, C.,Furze, R.C.,Grandi, P.,Michon, A.,Wellaway, C.,Barrett, N.,Bridges, A.M.,Craggs, P.D.,Diallo, H.,Dixon, D.P.,Douault, C.,Emmons, A.J.,Jones, E.J.,Karamshi, B.V.,Locke, K.,Mitchell, D.J.,Mouzon, B.H.,Prinjha, R.K.,Roberts, A.D.,Sheppard, R.J.,Watson, R.J.,Bamborough, P. Fragment-Based Discovery of Low-Micromolar Atad2 Bromodomain Inhibitors. J.Med.Chem., 58:5649-, 2015 Cited by PubMed: 26155854 DOI: 10.1021/ACS.JMEDCHEM.5B00772 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.97 Å)

Structure validation