5A5I

Cytochrome 2C9 P450 inhibitor complex

Summary for 5A5I

• Entry DOI: 10.2210/pdb5a5i/pdb
• Related: 5A5J
• Descriptor: CYTOCHROME P450 2C9, N-[4-(3-chloranyl-4-cyano-phenoxy)cyclohexyl]-1,1,1-tris(fluoranyl)methanesulfonamide, PROTOPORPHYRIN IX CONTAINING FE, ... (4 entities in total)
• Functional Keywords: oxidoreductase
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Endoplasmic reticulum membrane; Peripheral membrane protein: P11712
• Total number of polymer chains: 1
• Total formula weight: 55322.16

Authors

Skerratt, S.E.,de Groot, M.J.,Phillips, C. (deposition date: 2015-06-18, release date: 2016-08-24)

• Primary citation: Skerratt, S.E.,De Groot, M.J.,Phillips, C.; Discovery of a Novel Binding Pocket for Cyp 2C9 Inhibitors: Crystallography, Pharmacophore Modelling and Inhibitor Sar.; Med.Chem.Comm., 7:813-, 2016; DOI: 10.1039/C6MD00011H

Experimental method

X-RAY DIFFRACTION (2 Å)