5L7I

Structure of human Smoothened in complex with Vismodegib

Summary for 5L7I

Entry DOI	10.2210/pdb5l7i/pdb
Descriptor	Smoothened homolog,Soluble cytochrome b562,Smoothened homolog, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-chloranyl-~{N}-(4-chloranyl-3-pyridin-2-yl-phenyl)-4-methylsulfonyl-benzamide, ... (5 entities in total)
Functional Keywords	g protein coupled receptor, morphogen signaling, membrane protein, hedgehog signaling, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	143367.81
Authors	Byrne, E.X.B.,Sircar, R.,Miller, P.S.,Hedger, G.,Luchetti, G.,Nachtergaele, S.,Tully, M.D.,Mydock-McGrane, L.,Covey, D.F.,Rambo, R.F.,Sansom, M.S.P.,Newstead, S.,Rohatgi, R.,Siebold, C. (deposition date: 2016-06-03, release date: 2016-07-20, Last modification date: 2024-01-10)
Primary citation	Byrne, E.F.,Sircar, R.,Miller, P.S.,Hedger, G.,Luchetti, G.,Nachtergaele, S.,Tully, M.D.,Mydock-McGrane, L.,Covey, D.F.,Rambo, R.P.,Sansom, M.S.,Newstead, S.,Rohatgi, R.,Siebold, C. Structural basis of Smoothened regulation by its extracellular domains. Nature, 535:517-522, 2016 Cited by PubMed: 27437577 DOI: 10.1038/nature18934 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation