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5L7D

Structure of human Smoothened in complex with cholesterol

Summary for 5L7D
Entry DOI10.2210/pdb5l7d/pdb
DescriptorSmoothened homolog,Soluble cytochrome b562,Smoothened homolog, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... (4 entities in total)
Functional Keywordsg protein coupled receptor, morphogen signaling, hedgehog signaling, cholesterol, signaling protein, membrane protein
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains2
Total formula weight142442.99
Authors
Primary citationByrne, E.F.,Sircar, R.,Miller, P.S.,Hedger, G.,Luchetti, G.,Nachtergaele, S.,Tully, M.D.,Mydock-McGrane, L.,Covey, D.F.,Rambo, R.P.,Sansom, M.S.,Newstead, S.,Rohatgi, R.,Siebold, C.
Structural basis of Smoothened regulation by its extracellular domains.
Nature, 535:517-522, 2016
Cited by
PubMed: 27437577
DOI: 10.1038/nature18934
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.2 Å)
Structure validation

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