5GMF

Crystal structure of monkey TLR7 in complex with guanosine and polyU

Summary for 5GMF

• Entry DOI: 10.2210/pdb5gmf/pdb
• Related: 5GMG 5GMH
• Descriptor: Toll-like receptor 7, RNA (5'-R(P*UP*UP*UP*U)-3'), 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: immune system, tlr7, innate immunity, ssrna recogniton, immune system-rna complex, immune system/rna
• Biological source: Macaca mulatta (Rhesus macaque); More
• Total number of polymer chains: 8
• Total formula weight: 388598.87

Authors

Zhang, Z.,Ohto, U.,Shimizu, T. (deposition date: 2016-07-14, release date: 2016-11-02, Last modification date: 2023-11-08)

• Primary citation: Zhang, Z.,Ohto, U.,Shibata, T.,Krayukhina, E.,Taoka, M.,Yamauchi, Y.,Tanji, H.,Isobe, T.,Uchiyama, S.,Miyake, K.,Shimizu, T.; Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA; Immunity, 45:737-748, 2016; PubMed: 27742543; DOI: 10.1016/j.immuni.2016.09.011

Experimental method

X-RAY DIFFRACTION (2.5 Å)