5G0J

Crystal structure of Danio rerio HDAC6 CD1 and CD2 (linker intact) in complex with Nexturastat A

Summary for 5G0J

Entry DOI	10.2210/pdb5g0j/pdb
Related	5G0F 5G0G 5G0H 5G0I
Descriptor	HDAC6, CHLORIDE ION, ZINC ION, ... (6 entities in total)
Functional Keywords	cell cycle, histone, histone deacetylase
Biological source	DANIO RERIO (ZEBRAFISH)
Total number of polymer chains	1
Total formula weight	88187.62
Authors	Miyake, Y.,Keusch, J.J.,Wang, L.,Saito, M.,Hess, D.,Wang, X.,Melancon, B.J.,Helquist, P.,Gut, H.,Matthias, P. (deposition date: 2016-03-18, release date: 2016-07-27, Last modification date: 2024-01-10)
Primary citation	Miyake, Y.,Keusch, J.J.,Wang, L.,Saito, M.,Hess, D.,Wang, X.,Melancon, B.J.,Helquist, P.,Gut, H.,Matthias, P. Structural Insights Into Hdac6 Tubulin Deacetylation and its Selective Inhibition Nat.Chem.Biol., 12:748-, 2016 Cited by PubMed: 27454931 DOI: 10.1038/NCHEMBIO.2140 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.88 Å)

Structure validation