5EE7

Crystal structure of the human glucagon receptor (GCGR) in complex with the antagonist MK-0893

Summary for 5EE7

Entry DOI	10.2210/pdb5ee7/pdb
Descriptor	Glucagon receptor,Endolysin,Glucagon receptor, 3-[[4-[(1~{S})-1-[3-[3,5-bis(chloranyl)phenyl]-5-(6-methoxynaphthalen-2-yl)pyrazol-1-yl]ethyl]phenyl]carbonylamino]propanoic acid, OLEIC ACID, ... (6 entities in total)
Functional Keywords	gpcr, signaling protein, 7tm
Biological source	Homo sapiens (Human) More
Cellular location	Cell membrane ; Multi-pass membrane protein : P47871
Total number of polymer chains	1
Total formula weight	56370.97
Authors	Jazayeri, A.,Dore, A.S.,Lamb, D.,Krishnamurthy, H.,Southall, S.M.,Baig, A.H.,Bortolato, A.,Koglin, M.,Robertson, N.J.,Errey, J.C.,Andrews, S.P.,Brown, A.J.H.,Cooke, R.M.,Weir, M.,Marshall, F.H. (deposition date: 2015-10-22, release date: 2016-04-20, Last modification date: 2024-01-10)
Primary citation	Jazayeri, A.,Dore, A.S.,Lamb, D.,Krishnamurthy, H.,Southall, S.M.,Baig, A.H.,Bortolato, A.,Koglin, M.,Robertson, N.J.,Errey, J.C.,Andrews, S.P.,Teobald, I.,Brown, A.J.,Cooke, R.M.,Weir, M.,Marshall, F.H. Extra-helical binding site of a glucagon receptor antagonist. Nature, 533:274-277, 2016 Cited by PubMed: 27111510 DOI: 10.1038/nature17414 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation