5B41

Crystal structure of VDR-LBD complexed with 2-methylidene-19-nor-1a,25-dihydroxyvitamin D3

Summary for 5B41

• Entry DOI: 10.2210/pdb5b41/pdb
• Descriptor: Vitamin D3 receptor, Mediator of RNA polymerase II transcription subunit 1, (1R,3R)-5-(2-((1R,3aS,7aR,E)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-2- methylenecyclohexane-1,3-diol, ... (4 entities in total)
• Functional Keywords: transcription, vitamin d3, vdr, vdre, rxr, co-factors
• Biological source: Rattus norvegicus (Rat); More
• Total number of polymer chains: 2
• Total formula weight: 32582.57

Authors

Anami, Y.,Itoh, T.,Yamamoto, K. (deposition date: 2016-03-23, release date: 2016-12-07, Last modification date: 2023-11-08)

• Primary citation: Anami, Y.,Shimizu, N.,Ekimoto, T.,Egawa, D.,Itoh, T.,Ikeguchi, M.,Yamamoto, K.; Apo- and Antagonist-Binding Structures of Vitamin D Receptor Ligand-Binding Domain Revealed by Hybrid Approach Combining Small-Angle X-ray Scattering and Molecular Dynamics; J.Med.Chem., 59:7888-7900, 2016; PubMed: 27535484; DOI: 10.1021/acs.jmedchem.6b00682

Experimental method

X-RAY DIFFRACTION (1.89 Å)