4ZZH

SIRT1/Activator Complex

Summary for 4ZZH

• Entry DOI: 10.2210/pdb4zzh/pdb
• Descriptor: NAD-dependent protein deacetylase sirtuin-1, ZINC ION, (4S)-N-[3-(1,3-oxazol-5-yl)phenyl]-7-[3-(trifluoromethyl)phenyl]-3,4-dihydro-1,4-methanopyrido[2,3-b][1,4]diazepine-5(2H)-carboxamide (3 entities in total)
• Functional Keywords: sirtuin, activator, deacylase, complex, hydrolase-hydrolase activator complex, hydrolase/hydrolase activator
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus, PML body . SirtT1 75 kDa fragment: Cytoplasm : Q96EB6
• Total number of polymer chains: 1
• Total formula weight: 40682.14

Authors

Dai, H. (deposition date: 2015-05-22, release date: 2015-07-15, Last modification date: 2024-03-06)

• Primary citation: Dai, H.,Case, A.W.,Riera, T.V.,Considine, T.,Lee, J.E.,Hamuro, Y.,Zhao, H.,Jiang, Y.,Sweitzer, S.M.,Pietrak, B.,Schwartz, B.,Blum, C.A.,Disch, J.S.,Caldwell, R.,Szczepankiewicz, B.,Oalmann, C.,Yee Ng, P.,White, B.H.,Casaubon, R.,Narayan, R.,Koppetsch, K.,Bourbonais, F.,Wu, B.,Wang, J.,Qian, D.,Jiang, F.,Mao, C.,Wang, M.,Hu, E.,Wu, J.C.,Perni, R.B.,Vlasuk, G.P.,Ellis, J.L.; Crystallographic structure of a small molecule SIRT1 activator-enzyme complex.; Nat Commun, 6:7645-7645, 2015; PubMed: 26134520; DOI: 10.1038/ncomms8645

Experimental method

X-RAY DIFFRACTION (3.1001 Å)