4ZTZ

Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase

Summary for 4ZTZ

• Entry DOI: 10.2210/pdb4ztz/pdb
• Related: 4ZTU
• Descriptor: DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, DNA (25-MER), ... (6 entities in total)
• Functional Keywords: mitochondria, dna polymerase, processivity, drug toxicity, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 261520.90

Authors

Szymanski, M.R.,Yin, Y.W. (deposition date: 2015-05-15, release date: 2015-09-23, Last modification date: 2024-03-06)

• Primary citation: Szymanski, M.R.,Kuznestov, V.B.,Shumate, C.K.,Meng, Q.,Lee, Y.-S.,Patel, G.,Patel, S.S.,Yin, Y.W.; Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase; EMBO J., 34:1959-, 2015; PubMed: 26056153; DOI: 10.15252/embj.201591520

Experimental method

X-RAY DIFFRACTION (3.442 Å)