4ZTS

Human Aurora A catalytic domain bound to FK1142

Summary for 4ZTS

Entry DOI	10.2210/pdb4zts/pdb
Descriptor	Aurora kinase A, (2Z,5Z)-2-[(4-ethylphenyl)imino]-3-methyl-5-[(2-{[4-(1H-tetrazol-5-yl)phenyl]amino}pyridin-4-yl)methylidene]-1,3-thiazolidin-4-one, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (4 entities in total)
Functional Keywords	aurora, kinase, inhibitor, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965
Total number of polymer chains	1
Total formula weight	33549.51
Authors	Marcaida, M.J.,Kilchmann, F.,Schick, T.,Reymond, J.L. (deposition date: 2015-05-15, release date: 2016-07-20, Last modification date: 2024-01-10)
Primary citation	Kilchmann, F.,Marcaida, M.J.,Kotak, S.,Schick, T.,Boss, S.D.,Awale, M.,Gonczy, P.,Reymond, J.L. Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening. J.Med.Chem., 59:7188-7211, 2016 Cited by PubMed: 27391133 DOI: 10.1021/acs.jmedchem.6b00709 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation