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4ZTN

Irak4-inhibitor co-structure

Summary for 4ZTN
Entry DOI10.2210/pdb4ztn/pdb
Related4ZTL 4ZTM
DescriptorInterleukin-1 receptor-associated kinase 4, 5-(1,3-benzothiazol-2-yl)-2-(morpholin-4-yl)-6-[(3R)-piperidin-3-ylamino]pyrimidin-4(3H)-one (3 entities in total)
Functional Keywordskinase, phosphatase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm : Q9NWZ3
Total number of polymer chains4
Total formula weight137474.82
Authors
Fischmann, T.O. (deposition date: 2015-05-14, release date: 2015-09-02, Last modification date: 2023-09-27)
Primary citationSeganish, W.M.,Fischmann, T.O.,Sherborne, B.,Matasi, J.,Lavey, B.,McElroy, W.T.,Tulshian, D.,Tata, J.,Sondey, C.,Garlisi, C.G.,Devito, K.,Fossetta, J.,Lundell, D.,Niu, X.
Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors.
Acs Med.Chem.Lett., 6:942-947, 2015
Cited by
PubMed: 26288698
DOI: 10.1021/acsmedchemlett.5b00279
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.23 Å)
Structure validation

217705

数据于2024-03-27公开中

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